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LCT 0.047   Last updated EOD 20th November 2018
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Cell therapy for neurodegenerative diseases

LCT is an Australasian biotechnology company improving the wellbeing of people with serious diseases worldwide by discovering, developing and commercialising regenerative treatments which  include naturally occuring cells to restore function.

 

Our lead product, NTCELL®, is an alginate coated capsule containing clusters of neonatal porcine choroid plexus cells. After transplantation NTCELL functions as a biological factory, producing factors to promote new central nervous system growth and repair disease-induced nerve degeneration.

 

The Phase I/IIa clinical trial of NTCELL for the treatment of Parkinson’s disease, in New Zealand, met the primary endpoint of safety and in the three-year follow-up showed persistent long-term improvement in some patients.


Results from this trial were used to design a larger Phase IIb trial to confirm the most effective dose of NTCELL, define any placebo component of the response and further identify the initial target Parkinson’s disease patient sub group. This trial commenced in March 2016. 

 

 Initial analysis of the 18 month follow up data shows a statistically significant improvement
(p = <0.05) in the UPDRS in the patients who received 80 NTCELL capsules implantation to the putamen on both sides of the brain as compared to the placebo group that received sham surgery. 


In addition to Parkinson’s disease, NTCELL has the potential to be used in a number of other central nervous system indications, including Huntington’s, Alzheimer’s and motor neurone diseases including amyotrophic lateral sclerosis (ALS).

 

LCT’s proprietary encapsulation technology, IMMUPEL™, allows cell therapies to be used without the need for co-treatment with drugs that suppress the immune system.

 

LCT is listed on the Australian (ASX: LCT) and US (OTCQX: LVCLY) stock exchanges and is incorporated in Australia, with operations based in New Zealand.

— 15 October 2018

Results of the AGM

In accordance with ASX Listing Rule 3.13.2 and section 251AA of the Corporations Act, we advise details of the resolutions and the proxies received in respect of each resolution, which are set out in the proxy summary.

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— 15 November 2018

Presentation to AGM - Dr Ken Taylor

Presentation to Annual General Meeting by CEO, Dr Ken Taylor.

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— 16 September 2017

Sir Richard Faull on RNZ National

On Saturday Morning on RNZ National, LCT Scientific Advisor Sir Richard Faull and businessman Bernie Crosby talk to Kim Hill about the work of the University of Auckland Centre for Brain Research and finding a cure for Parkinson's disease.

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— 13 June 2017

Pig brain cells implanted into brains of people with Parkinson’s

Would you have pig cells implanted in your brain? Some people with Parkinson’s disease have, in the hope it will stop their disease progressing. The approach is still in the early stages of testing, but initial results from four people look promising, with all showing some improvement 18 months after surgery. Living Cell Technologies, based in Auckland, New Zealand, has been developing a treatment that uses cells from the choroid plexus in pigs. This brain structure makes a cocktail of growth factors and signalling molecules known to help keep nerve cells healthy.

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Announcements

— 15 October 2018

Results of the AGM

In accordance with ASX Listing Rule 3.13.2 and section 251AA of the Corporations Act, we advise details of the resolutions and the proxies received in respect of each resolution, which are set out in the proxy summary.

Read More Read Less

— 15 November 2018

Presentation to AGM - Dr Ken Taylor

Presentation to Annual General Meeting by CEO, Dr Ken Taylor.

Read More Read Less
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LCT in the News

— 16 September 2017

Sir Richard Faull on RNZ National

On Saturday Morning on RNZ National, LCT Scientific Advisor Sir Richard Faull and businessman Bernie Crosby talk to Kim Hill about the work of the University of Auckland Centre for Brain Research and finding a cure for Parkinson's disease.

Read More Read Less

— 13 June 2017

Pig brain cells implanted into brains of people with Parkinson’s

Would you have pig cells implanted in your brain? Some people with Parkinson’s disease have, in the hope it will stop their disease progressing. The approach is still in the early stages of testing, but initial results from four people look promising, with all showing some improvement 18 months after surgery. Living Cell Technologies, based in Auckland, New Zealand, has been developing a treatment that uses cells from the choroid plexus in pigs. This brain structure makes a cocktail of growth factors and signalling molecules known to help keep nerve cells healthy.

Read More Read Less
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Events
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There are no forthcoming events at present.

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