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Fact sheet
The following fact sheets provide a summary of our current business and research pipeline.
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Fact sheet

The following fact sheet provides a summary of our current business and research pipeline.

Cell therapy for neurodegenerative diseases

Living Cell Technologies Limited (LCT) is an Australasian biotechnology company improving the wellbeing of people with serious diseases worldwide by discovering, developing and commercialising regenerative treatments which restore function using naturally occurring cells.

 

Our lead product, NTCELL®, is an alginate coated capsule containing clusters of neonatal porcine choroid plexus cells. After transplantation NTCELL functions as a biological factory, producing factors to promote new central nervous system growth and repair disease-induced nerve degeneration.

 

A Phase IIb trial of NTCELL for Parkinson's disease is currently underway. It aims to confirm the most effective dose of NTCELL, define any placebo component of the response and further identify the initial target Parkinson’s disease patient sub group. If the trial is successful LCT will apply for provisional consent to treat paying patients in New Zealand and launch NTCELL as the first disease modifying treatment for Parkinson’s disease, in 2017.

 

In addition to Parkinson’s disease, NTCELL has the potential to be used in a number of other central nervous system indications, including Huntington’s, Alzheimer’s and motor neurone diseases including amyotrophic lateral sclerosis (ALS).

 

LCT’s proprietary encapsulation technology, IMMUPEL™, allows cell therapies to be used without the need for co-treatment with drugs that suppress the immune system.

 

LCT is listed on the Australian (ASX: LCT) and US (OTCQX: LVCLY) stock exchanges and is incorporated in Australia, with operations based in New Zealand.

— 6 June 2017

NTCELL® continues to halt progression of Parkinson’s disease

130 weeks after treatment all four patients who took part in Living Cell Technologies Limited’s Phase I/IIa clinical study of NTCELL® for Parkinson’s disease remain well and there are no safety concerns. The primary clinical endpoint of this initial open clinical study, involving the implantation of 40 NTCELL capsules into the putamen on one side of the brain only, is safety. In all patients NTCELL treatment continues to show improvement over baseline, as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS). The Principal Investigator, Dr Barry Snow, Auckland City Hospital, says the sustained improvement is interesting and encouraging. “The results to date certainly validate the Phase IIb dose ranging study in progress, in which higher doses of NTCELL are implanted into the putamen on both sides of the brain and which includes a sham surgical-controlled placebo group.” Dr Ken Taylor, CEO of LCT, says, “As this initial trial of a low dose of NTCELL was designed to measure safety, we are happy that the primary endpoint continues to be met. We are looking forward to the results of the larger Phase IIb study initiated this year which is designed to measure efficacy. This study will confirm the most effective dose of NTCELL, define any placebo component of the response and further identify the initial target Parkinson’s disease patient sub-group. “Our goal, subject to continued satisfactory data, remains to obtain provisional consent and launch NTCELL as the first disease modifying treatment for Parkinson’s disease in 2018,” says Dr Taylor.

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— 16 May 2017

LCT collaborates with Centre for Brain Research to extend product pipeline

Living Cell Technologies Limited has initiated a research collaboration with the Centre for Brain Research (CBR) at the University of Auckland. The research collaboration will explore how LCT’s products can reverse human brain neurodegenerative processes associated with pericytes (and other brain cells), which help sustain the blood-brain barrier and other homeostatic and haemostatic functions in the brain.

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— 13 June 2017

Pig brain cells implanted into brains of people with Parkinson’s

Would you have pig cells implanted in your brain? Some people with Parkinson’s disease have, in the hope it will stop their disease progressing. The approach is still in the early stages of testing, but initial results from four people look promising, with all showing some improvement 18 months after surgery. Living Cell Technologies, based in Auckland, New Zealand, has been developing a treatment that uses cells from the choroid plexus in pigs. This brain structure makes a cocktail of growth factors and signalling molecules known to help keep nerve cells healthy.

Read More Read Less

— 1 March 2016

LCT expects crucial Parkinson’s clinical trial results in early 2017

Australasian biotech company Living Cell Technologies says it will know the outcome of a make-or-break clinical trial on its regenerative cell therapy for Parkinson's disease in the first quarter of next year. If the trial succeeds, Living Cell's lead product NTCELL will be the world's first disease-modifying treatment for Parkinson's as existing treatments only deal with the symptoms rather than stopping the degeneration of the brain.

Read More Read Less
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There are no forthcoming events at present.

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Announcements

— 6 June 2017

NTCELL® continues to halt progression of Parkinson’s disease

130 weeks after treatment all four patients who took part in Living Cell Technologies Limited’s Phase I/IIa clinical study of NTCELL® for Parkinson’s disease remain well and there are no safety concerns. The primary clinical endpoint of this initial open clinical study, involving the implantation of 40 NTCELL capsules into the putamen on one side of the brain only, is safety. In all patients NTCELL treatment continues to show improvement over baseline, as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS). The Principal Investigator, Dr Barry Snow, Auckland City Hospital, says the sustained improvement is interesting and encouraging. “The results to date certainly validate the Phase IIb dose ranging study in progress, in which higher doses of NTCELL are implanted into the putamen on both sides of the brain and which includes a sham surgical-controlled placebo group.” Dr Ken Taylor, CEO of LCT, says, “As this initial trial of a low dose of NTCELL was designed to measure safety, we are happy that the primary endpoint continues to be met. We are looking forward to the results of the larger Phase IIb study initiated this year which is designed to measure efficacy. This study will confirm the most effective dose of NTCELL, define any placebo component of the response and further identify the initial target Parkinson’s disease patient sub-group. “Our goal, subject to continued satisfactory data, remains to obtain provisional consent and launch NTCELL as the first disease modifying treatment for Parkinson’s disease in 2018,” says Dr Taylor.

Read More Read Less

— 16 May 2017

LCT collaborates with Centre for Brain Research to extend product pipeline

Living Cell Technologies Limited has initiated a research collaboration with the Centre for Brain Research (CBR) at the University of Auckland. The research collaboration will explore how LCT’s products can reverse human brain neurodegenerative processes associated with pericytes (and other brain cells), which help sustain the blood-brain barrier and other homeostatic and haemostatic functions in the brain.

Read More Read Less
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LCT in the News

— 13 June 2017

Pig brain cells implanted into brains of people with Parkinson’s

Would you have pig cells implanted in your brain? Some people with Parkinson’s disease have, in the hope it will stop their disease progressing. The approach is still in the early stages of testing, but initial results from four people look promising, with all showing some improvement 18 months after surgery. Living Cell Technologies, based in Auckland, New Zealand, has been developing a treatment that uses cells from the choroid plexus in pigs. This brain structure makes a cocktail of growth factors and signalling molecules known to help keep nerve cells healthy.

Read More Read Less

— 1 March 2016

LCT expects crucial Parkinson’s clinical trial results in early 2017

Australasian biotech company Living Cell Technologies says it will know the outcome of a make-or-break clinical trial on its regenerative cell therapy for Parkinson's disease in the first quarter of next year. If the trial succeeds, Living Cell's lead product NTCELL will be the world's first disease-modifying treatment for Parkinson's as existing treatments only deal with the symptoms rather than stopping the degeneration of the brain.

Read More Read Less
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Events

There are no forthcoming events at present.

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Register for email updates
Register now to receive our newsletter and updates on LCT’s activities and progress.